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The onset of action after oral administration of the available PDE5 inhibitors may be within 30 min; however, most men require at least 60 min delay after taking the medication (up to 2 h with tadalafil, while avanafil and vardenafil have the shortest onsets of action).
The bioequivalence test was fully satisfied for sildenafil and N-desmethyl-sildenafil in terms of rate and extent of bioavailability.
There was a washout interval of ≥7 days between the two administrations of the investigational medicinal products.
Blood samples for pharmacokinetic analysis were collected up to 24 h post-dosing.
Orally disintegrating film and tablet formulations of PDE5 inhibitors that disintegrate in the patient’s mouth without the need for swallowing with water have been developed.
requiring only a small amount of saliva on the tongue to dissolve within a few minutes of administration.