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In colorectal cancer currently used experimental techniques suffer from limitations, hampering widespread clinical implementation of the technique. However, the worldwide availability of radioisotopes, and therefore the best treatment, is limited. In colorectal cancer, the objective is to introduce a SLN procedure allowing to improve nodal staging accuracy in a routine clinical workflow after ex vivo administration of magnetic nanoparticles.
The SLNs therefore play a crucial role in the staging and treatment of cancer.
This thesis describes the use of magnetic nanoparticles for SLN identification in colorectal- and breast cancer.
The experimental findings are compared with calculated magnetic anisotropy contributions of the three different types of deposited nanoparticles (NPs).
It was found that despite their different atomic structure, the body-centered cubic (bcc) iron and face-centered cubic (fcc) cobalt nanoparticles have a similar behavior and can exist in a state which demonstrates an unexpected ferromagnetic (FM) behavior with sizes down to 8 nm at room temperature (RT), while nickel particles only exhibit the expected superparamagnetic (SPM) behavior.
The thesis addresses a subject with broad implications in various scientific and technical areas.
Magnetic Nanoparticles Thesis